Born in Makkah in 1943, he was the second son of Prince Abdullah Al-Faisal. His mother was Princess Al-Jawhara bint Khaled bin Mohammed bin Abdul Rahman Al-Saud.
Prince Mohammed studied at the Model Schools in Taif until he completed his intermediate education. He completed his secondary education in Lauzene after which he joined the university of Fairbourne where he graduated with a B.A. degree in commercial sciences. He spoke fluent French.
Prince Mohammed held a number of positions in the Saudi government. He worked as an accountant at the Saudi Arabian Monetary Agency (SAMA) in Jeddah for two years. Before that he was sent by the Saudi British Bank to a study course in England for eight months. He then joined the Ministry of Education where he worked as director of organization and administration. He then became director general of scholarships and cultural relations and after that director general of administrative and financial affairs until he was promoted to assistant undersecretary for the administrative and financial affairs of the Ministry of Education.
While with the ministry, he established its organizational structure, chaired the team of administration and organization and introduced the feeding system for school students. He left the ministry to dedicate all his time to his own private business.
Prince Mohammed owned and managed a number of companies and establishments. He was chairman of the board of directors of: the Qasim Cement Company, Al-Faisal Group, the International Takamul Company for Commercial Investments and the Takamul National Agricultural Company. He was one of the founders of the Arab Thought Foundation, member of its board of trustees and member of the board of trustees of King Faisal Welfare Foundation.
Prince Mohammed was a poet and a sportsman. He was one of the founders of the Al-Ahli Sport Club in Jeddah. He initiated a board of honorary members for the club. He supported the club which was sponsored by his father Prince Abdullah Al-Faisal in 1950. In 1980 be became chairman of the board of directors of the club and in 2002 a member of its board of honorary members. He supervised the soccer team and was able to achieve a number of championships. He also organized a number of sport events including the Annual Friendship Tournament in Aha which was officially recognized by the International Football Federation (FIFA) in 2004. He also initiated a tournament for the youth under 23 years of age which continued for a year and stopped.
Prince Mohammed was known for his passion for culture and art. He was always present in the media arena and maintained close ties with the sportsmen, the literary men and journalists. He had a sharp eye for discovering talents in sports, literature and other fields. He had discovered many hidden talents who later became stars and famous people. Over more than four decades, he had made great contributions to the local poetry. His poetic style was a blend between the old and the new.
Prince Mohammed was a song writer. Many singers sang his sons including: Talal Maddah, who sang 50 lyrics written by him, Mohammed Abdou, Abadi Al-Jawhar, Abdul Majeed Abdullah, Abdul Kareem Abdul Qadir and others. Many Arab singers also sang his songs. They were: Nabeel Shuail of Kuwait, Kazim Al-Sahir of Iraq, Nancy Ajram of Lebanon and others.
Prince Mohammed was fond of horse riding, hunting and poetry writing.
He was married twice and has eight sons and daughters who are: Turki, Noura, Khaled, Fahd, Talal, Saud, Sultan and Haifa.